Key publications


Multi-color single-molecule imaging uncovers extensive heterogeneity in mRNA decoding

Boersma S*, Khuperkar D*, Verhagen BMP, Sonneveld S, Grimm JB, Lavis LD and Tanenbaum ME.

Cell 2019; 178, 1-15 PDF

Single-molecule imaging uncovers rules governing nonsense-mediated mRNA decay

Hoek TA*, Khuperkar D*, Lindeboom RGH, Sonneveld S, Verhagen BMP, Boersma S, Vermeulen M, Tanenbaum ME.

Mol Cell. 2019; July 25; 75,1-16. PDF


Imaging Translation Dynamics of Single mRNA Molecules in Live Cells.

Ruijtenberg S, Hoek TA, Yan X, Tanenbaum ME.

Methods Mol Biol. 2018;1649:385-404. PDF

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Jost M, Chen Y*, Gilbert LA*, Horlbeck MA*, Krenning L*, Menchon G*, Rai A*, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME# and Weissman JS#              # Corresponding authors   * Equal contributions

Mol Cell. 2017 Oct 5;68(1):210-223.e6. PDF

Cell scientist to watch – Marvin Tanenbaum

J Cell Sci. 2017 130: 817-818; PDF


Dynamics of Translation of Single mRNA Molecules In Vivo.

Yan X, Hoek TA, Vale RD and Tanenbaum ME.  

Cell. 2016 May 5;165(4):976-89 PDF

Research highlights in: Science, Nature Biotechnology, Nature Methods, Nature reviews Molecular Cell Biology, Molecular Cell, Trends in Biochemical sciences, Science Bulletin, Faculty of 1000, The Scientist



Regulation of mRNA translation during mitosis.

Tanenbaum ME, Stern-Ginossar N, Weissman JS and Vale RD.

eLife. 2015 Aug 25;4 PDF

Research highlights in: Nature reviews Molecular Cell Biology



A protein tagging system for signal amplification in gene transcription and fluorescence imaging.

Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS and Vale RD. 

Cell Oct. 23, 2014 PDF

Research highlights in: Nature Methods, ACS Chemical Biology, Biotechniques and The Scientist

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.

McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G and Vale RD. 

Science. 2014 Jul 18;345(6194):337-41 PDF




Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains.

Tanenbaum ME*, Vale RD and McKenney RJ*. *Equal contributions

eLife. 2013 Sep 3;2:e00943 PDF




Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation .

Raaijmakers JA, van Heesbeen RG, Meaders JL, Geers EF, Fernandez-garcia B, Medema RH and Tanenbaum M.E.

EMBO J. 2012 Nov 5;31(21):4179-90. PDF




A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.

Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A and Medema RH.

Curr Biol. 2011 Aug 23;21(16):1356-65. PDF




Mechanisms of centrosome separation and bipolar spindle assembly.

Tanenbaum ME, and Medema RH.

Dev Cell. 2010 Dec 14;19(6):797-806. PDF


Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.

Splinter D*, Tanenbaum ME*, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, Akhmanova A. * Equal contributions

PLoS Biol. 2010 Apr 6;8(4):e1000350. PDF




Kif15 cooperates with eg5 to promote bipolar spindle assembly.

Tanenbaum ME, Macurek L, Janssen A, Geers EF, Alvarez-Fernandez M, and Medema RH.

Curr Biol. 2009 Nov 3;19(20):1703-11. PDF




Dynein, Lis1 and CLIP170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.

Tanenbaum ME, Macurek L., Galjart N, and Medema RH.

EMBO J. 2008 Dec 17;27(24):3235-45. PDF